SCIENTIFIC USE CASES

See what you can do
with Scout.

Use Scout to investigate scientific questions, evaluate evidence, compare hypotheses, prioritize what to pursue, and plan the next step — across the research process.

TARGET DISCOVERY BIOMARKER RESEARCH INDICATION EXPANSION LEAD PRIORITIZATION
TARGET DISCOVERY Which targets show the strongest evidence for this disease?
INDICATION EXPANSION What additional indications are supported by this mechanism?
LEAD PRIORITIZATION Which compounds should we advance to experimental validation?
SCIENTIFIC INTELLIGENCE What has changed in the evidence since we last evaluated this program?
WHERE SCOUT FITS

Move more scientific work upstream.

Scout is most valuable where scientists are asking questions that require many steps, many sources, and many scientific tools to answer well.

Instead of manually moving between literature, databases, models, and analysis tools, scientists give Scout the research objective. Scout determines the work required, executes it, and synthesizes the evidence into an inspectable result.

01 · RESISTANCE TARGET DISCOVERY

Find mechanisms of resistance to KRAS G12C inhibitors.

Example question: “What targets and pathways are most strongly implicated in acquired resistance to KRAS G12C inhibition in NSCLC?” Scout can assemble published resistance mechanisms, genes, pathway evidence, expression findings, and supporting citations into ranked hypotheses for follow-up.

Resistance mechanismsTarget hypothesesEvidence rankingCitations
02 · TARGET VALIDATION

Pressure-test a new oncology target before advancing it.

Example question: “Build the case for and against inhibiting this target in pancreatic cancer.” Scout can investigate disease association, genetics, expression, pathway biology, published perturbation evidence, known liabilities, and contradictory findings — then show where the hypothesis is strong and where evidence is missing.

Pro / con evidenceBiological rationaleEvidence gapsNext experiments
03 · INDICATION EXPANSION

Find new indications for an existing asset.

Example question: “Given this molecule’s mechanism and target profile, what additional disease indications have the strongest biological rationale?” Scout can connect mechanism of action to disease pathways, genetic associations, published evidence, related clinical activity, and competitive programs to prioritize expansion hypotheses.

Indication rankingMechanistic rationaleClinical contextCompetitive activity
04 · HIT / LEAD PRIORITIZATION

Choose which compounds move into experimental testing.

Example question: “Rank these 40 compounds for progression based on potency, selectivity, predicted ADMET, structural fit, and known liabilities.” Scout can coordinate the required analyses, compare candidates against the same criteria, and produce an evidence-backed shortlist for scientist review.

Ranked compoundsADMETStructural evidenceLiability flags
05 · EARLY LIABILITY ASSESSMENT

Identify why a promising molecule could fail later.

Example question: “What developability risks should we investigate before advancing this lead series?” Scout can evaluate predicted ADME, toxicity, physicochemical properties, off-target concerns, and literature-reported liabilities to surface risks before additional wet-lab investment.

Risk profileToxicity signalsADMEFollow-up tests
06 · RESPONSE BIOMARKER DISCOVERY

Find biomarkers that may explain treatment response.

Example question: “Which biomarkers could distinguish responders from non-responders for this mechanism?” Scout can investigate gene and protein expression, pathway context, disease subtypes, published response associations, and mechanistic evidence to generate biomarker hypotheses for validation.

Biomarker hypothesesExpression evidenceMechanismValidation rationale
07 · COMPETITIVE SCIENTIFIC LANDSCAPE

Map who is pursuing a target — and how.

Example question: “Who is developing therapies against this target, which modalities are they using, and where is there scientific whitespace?” Scout can connect companies, assets, mechanisms, publications, and clinical programs to create a research-driven view of the competitive field.

Companies + assetsModalitiesClinical programsWhitespace
08 · SCIENTIFIC DUE DILIGENCE

Evaluate the science behind an external asset.

Example question: “What evidence supports this asset and mechanism, what contradicts it, and what should we investigate before licensing?” Scout can synthesize target biology, mechanism, published studies, clinical evidence, competitive context, and unresolved scientific questions into a cited diligence package.

Evidence packageRed flagsCompetitive contextDiligence questions
FROM USE CASE TO PLATFORM

Scout is the scientist.
SigmaticOS is what lets it scale.

Start with a research question in Scout. As your needs grow, SigmaticOS can extend autonomous science into the tools, methods, pipelines, systems, and experimental environment your organization already uses.

SCOUT

Ask the scientific question

Scientists interact in natural language while Scout plans, executes, and synthesizes the research.

SIGMATICOS

Orchestrate your scientific stack

Connect commercial tools, proprietary methods, scientific agents, data, and reusable pipelines.

LAB-IN-THE-LOOP

Close the experimental loop

Connect LIMS + ELN and experimental systems so real-world evidence can inform what happens next.

PUT YOUR USE CASE TO SCOUT

Have a research question you want to test?

Show us the scientific problem. We’ll tailor the demo around the kind of work your team actually needs to do — not a canned product tour.

01

Bring the question. Target hypothesis, asset, molecule set, disease area, diligence question, or research workflow.

02

See Scout approach the work. We’ll show how Scout plans, executes, and synthesizes a multi-step scientific research program.

03

Go deeper when it matters. Explore SigmaticOS, proprietary methods, enterprise tools, LIMS + ELN, or Lab-in-the-Loop where relevant.

REQUEST A DEMO

Make it about your science.

Tell us what your team is working on and what you want to explore. We’ll use that context to make the session relevant from the start.